There are a number of factors which lead to Vein Reflux Disease:

Heredity - The risk of vein reflux disease is most commonly attributed to the hereditary traits of one's family.

Gender - Women have a higher incidence of vein reflux disease due, in part, to the female hormones affecting the structure of the vein walls.

Pregnancy - Pregnancy can cause an increase in blood pressure, which results in more pressure and stress on the walls of the vein.

Age - As we age, our tissues lose elasticity, resulting in weakened vein walls and valves.

There are additional factors which do not cause vein reflux, but will expedite the development and severity of the disease:

Obesity - A substantial increases in weight will often increase blood pressure an stress on vein walls.

Prolonged Standing - The volume and pressure of blood in the lower limbs is affected by gravity, so the longer you stand the greater the effect.

Physical Trauma - Sometimes trauma to the lower limbs can damage the underlying blood vessels and add to the problem of vein reflux disease.